By design, clinical trials ask their participants to take on risk. To develop new vaccines, drugs, or therapies, scientists first have to ask volunteers to try out those interventions, with no guarantee that they’ll work or be free of side effects. To minimize harm, researchers promise to care for and monitor participants through a trial’s end, long enough to collect the data necessary to determine if a therapy is effective and at what cost.
For most of the past century, the United States’ track record on infectious disease has been quite good. Thanks to major investments in public health, diseases such as smallpox, polio, yellow fever, malaria, measles, rubella, mumps, diphtheria, and tuberculosis have either been obliterated or become vanishingly rare. America “led the charge,” Aniruddha Hazra, an infectious-disease physician at UChicago Medicine, told me.
On the afternoon of Friday, February 7, as staff members were getting ready to leave the headquarters of the National Institutes of Health, just outside Washington, D.C., officials in the Office of Extramural Research received an unexpected memo. It came from the Department of Health and Human Services, which oversees the NIH, and arrived with clear instructions: Post this announcement on your website immediately.
Updated at 5:53 p.m. on January 31, 2025
Last night, scientists began to hear cryptic and foreboding warnings from colleagues: Go to the CDC website, and download your data now. They were all telling one another the same thing: Data on the website were about to disappear, or be altered, to comply with the Trump administration’s ongoing attempt to scrub federal agencies of any mention of gender, DEI, and accessibility. “I was up until 2 a.m.
Put on the spot, a lot of Americans might hesitate over the difference between Medicaid and Medicare. People who aren’t affected by one of these programs, which together enroll about 150 million people in the U.S., don’t generally have a need to be well versed in their intricacies, and the two programs sound quite similar.
Becoming a public-health expert means learning how to envision humanity’s worst-case scenarios for infectious disease. For decades, though, no one in the U.S. has had to consider the full danger of some of history’s most devastating pathogens. Widespread vaccination has eliminated several diseases—among them, measles, polio, and rubella—from the country, and helped keep more than a dozen others under control.
For more than 60 years, vaccination in the United States has been largely shaped by an obscure committee tasked with advising the federal government. In almost every case, the nation’s leaders have accepted in full the group’s advice on who should get vaccines and when. Experts I asked could recall only two exceptions.
At the start of Elizabeth Hobson’s career as an ecologist, she knew to stick to one rule: Never anthropomorphize the animals you study.
For plenty of people, assigning human characteristics to another living creature feels natural enough that we do it as a matter of course. But to many scientists who study animal behavior, anthropomorphism is a cardinal sin, and suggesting that a researcher has tiptoed in that direction is tantamount to saying they’ve resorted to uninformed speculation.
Every year, beginning around the end of March, my household starts planning a massacre. Our targets are our home’s clothes moths: My spouse and I lay pheromone-laced traps in the closets, living room, and bedrooms; we—and our two cats—go on alert for any stray speckle of brown on a cream-colored wall. The moment we spy an insect, we’ll do whatever we can to crush it. After killing dozens upon dozens, my husband and I can now snatch moths straight out of the air.
Of all the creatures stricken with this new and terrible H5N1 flu—the foxes, the bears, the eagles, ducks, chickens, and many other birds—dairy cattle are some of the most intimate with us. In the United States, more than 9 million milk cows live on farms, where people muck their manure, help birth their calves, tend their sick, and milk them daily.
At the start of the spring of 2015, Jeffrey, a three-year-old meerkat, was happily eating, tussling with his brothers, and surveying zoo patrons from his usual perch, his forepaws gathered and his black-tipped snout aloft. But one day in April, his caretakers discovered him in his enclosure, so weak that he could barely lift his head. By the time he was brought to Eric Baitchman, the head vet at Massachusetts’s Stone Zoo, Jeffrey was losing consciousness.
Shortly before I started college, I finally wised up to the fact that fluency in my parents’ native language of Mandarin Chinese might be an asset. But after nearly two decades of revolting against my parents’ desperate attempts to keep me in Chinese school, I figured I was toast. Surely, by then, my brain and vocal tract had aged out of the window in which they could easily learn to discern and produce tones.
Earlier today, The New York Times broke some startling news about a presidential candidate. According to a 2012 deposition, Robert F. Kennedy Jr. once suffered from, in his own words, “a worm that got into my brain and ate a portion of it and then died.” The vague yet alarming description could apply to any number of parasitic ailments, among them angiostrongyliasis, baylisascariasis, toxocariasis, strongyloidiasis, and trichinosis.
When Kathleen Walker-Meikle, a historian at the University of Basel, in Switzerland, ponders the Middle Ages, her mind tends to drift not to religious conquest or Viking raids, but to squirrels. Tawny-backed, white-bellied, tufted-eared red squirrels, to be exact. For hundreds of years, society’s elites stitched red-squirrel pelts into luxurious floor-length capes and made the animals pets, cradling them in their lap and commissioning gold collars festooned with pearls.
The ongoing outbreak of H5N1 avian flu virus looks a lot like a public-health problem that the United States should be well prepared for.
Although this version of flu is relatively new to the world, scientists have been tracking H5N1 for almost 30 years. Researchers know the basics of how flu spreads and who tends to be most at risk. They have experience with other flus that have jumped into us from animals. The U.S.
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Within the next couple of decades, a new generation of contraceptives could hit the American market. One, a pill that blocks certain cells from accessing vitamin A, might be able to limit fertility without flooding the body with hormones; another is an injection that temporarily blocks up the reproductive plumbing.
Updated at 6:50 p.m. ET on March 15, 2024
At about 3:30 a.m., four hours into our drive, Travis Livieri’s phone began to thrum. “I’ve got a ferret for you,” a voice crackled through the static. The animal in question was one of North America’s most endangered mammals, for which the next hour might be the strangest of her life; for Livieri, the wildlife biologist tasked with saving her, it would be one of thousands of interventions he’s made to prevent her kind from permanently vanishing.
Four years after what was once the “novel coronavirus” was declared a pandemic, COVID remains the most dangerous infectious respiratory illness regularly circulating in the U.S. But a glance at the United States’ most prominent COVID policies can give the impression that the disease is just another seasonal flu.
In the late aughts, while working on the island of Jersey, in the United Kingdom, Erica Cartmill found herself staring at a daughter giving her mother some grief.
The little one was waving a stick in her mother’s face and then yanking it back when her mother reached to snatch the object away—a performance so persistent, so targeted, Cartmill told me, that it was almost impossible for the grown-up to ignore.
In Arnold Monto’s ideal vision of this fall, the United States’ flu vaccines would be slated for some serious change—booting a major ingredient that they’ve consistently included since 2013. The component isn’t dangerous. And it made sense to use before. But to include it again now, Monto, an epidemiologist and a flu expert at the University of Michigan, told me, would mean vaccinating people “against something that doesn’t exist.
Out on the savannas of East Africa, lions have always loomed large. Clocking in at several hundred pounds apiece and capable of ending a zebra’s life in a single swift bite, they’re veritable food-web royalty.
But in certain parts of their habitat, these hefty carnivores are now under threat from an unlikely and petite new nemesis: an invasive ant, puny enough to fit inside a hollowed-out sesame seed. The two creatures rarely, if ever, directly interact.
Across the Northeast, forests are haunted by the ghosts of American giants. A little more than a century ago, these woods brimmed with American chestnuts—stately Goliaths that could grow as high as 130 feet tall and more than 10 feet wide. Nicknamed “the redwoods of the East,” some 4 billion American chestnuts dotted the United States’ eastern flank, stretching from the misty coasts of Maine down into the thick humidity of Appalachia.
Earlier this month, Taison Bell walked into the intensive-care unit at UVA Health and discovered that half of the patients under his care could no longer breathe on their own. All of them had been put on ventilators or high-flow oxygen.
In Linfa Wang’s ideal world, all humans would be just a bit more bat-like.Wang, a biochemist and zoonotic-disease expert at Duke-NUS Medical School, in Singapore, has no illusions about people flapping about the skies or echolocating to find the best burger in town. The point is “not to live like a bat,” Wang told me, but to take inspiration from their very weird physiology in order to boost the quality, or even the length, of human life.
In the early 1990s, while studying preeclampsia in Guadeloupe, Pierre-Yves Robillard hit upon a realization that seemed to shake the foundations of his field. Preeclampsia, a pregnancy complication that causes some 500,000 fetal deaths and 70,000 maternal deaths around the world each year, had for decades been regarded as a condition most common among new mothers, whose bodies were mounting an inappropriate attack on a first baby.
As the chair of the department of obstetrics and gynecology at UT Southwestern Medicine, Catherine Spong is used to seeing a lot of baby bumps. But through her decades of practice, she’s been fascinated by a different kind of bump: Year after year after year, she and her colleagues deliver a deluge of babies from June through September, as much as a 10 percent increase in monthly rates over what they see from February through April. “We call it the summer surge,” Spong told me.
Paul Offit is not an anti-vaxxer. His résumé alone would tell you that: A pediatrician at Children’s Hospital of Philadelphia, he is the co-inventor of a rotavirus vaccine for infants that has been credited with saving “hundreds of lives every day”; he is the author of roughly a dozen books on immunization that repeatedly debunk anti-vaccine claims. And from the earliest days of COVID-19 vaccines, he’s stressed the importance of getting the shots.
Back in the spring, around the end of the COVID-19 public-health emergency, hospitals around the country underwent a change in dress code. The masks that staff had been wearing at work for more than three years vanished, in some places overnight.
This article was featured in One Story to Read Today, a newsletter in which our editors recommend a single must-read from The Atlantic, Monday through Friday. Sign up for it here.For years, the American approach to protein has been a never-ending quest for more. On average, each person in the United States puts away roughly 300 pounds of meat a year; we are responsible for more than a third of the multibillion-dollar protein-supplement market.
Anoles have always been happy in the heat. The svelte little lizards, a group some 400 species strong, thrive in the Americas’ warmest parts—from the balmy rainforests of South America up through the United States’ Sun Belt—where they spend their days basking on boulders and scurrying out to the sun-soaked tips of twigs, or even scampering over the blistering metal of exposed city pipes.